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KMID : 0350519930460041729
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Journal of Catholic Medical College
1993 Volume.46 No. 4 p.1729 ~ p.1738
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Localized In vivo 1H MRS Study on Proton Metabolic Abnormalities of the Right Prefrontal Lobe in Drug-Na?e Schizophrenics
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Abstract
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Localized, water-suppressed in vivo 1H magnetic resonance spectroscopy(1H MRS) was applied to the evaluation of the proton metabolic alterations in the right prefrontal white matter in schizophrenics and normal control subjects. The study
included
10
normal adult volunteers and 11 schizophrenics [drug-na?e (n=7) and suspension of more than 6 months drum treatment (n=4) ]. All underwent MRS with a Point RESolved Spectroscopy (PRESS) pulse sequence that provided 2×2×2㎤of volume of interest
(VOI).
The normal sepctra was characterized as typical signal peaks of N-acetylaspartate (NAA) 2.0 ppm, gamma-aminobutyric acid 9GABA) 2.25 ppm, glutamate (Glu) 2.35 ppm, creatine/phosphocreatine (Cr) 3.0 ppm and choline/phosphocholine (Cho) 3.2 ppm.
The
specific spectral features demonstrated in the patient group were an incrase in Cr and GABA signal intensities and a decrease in NAA and Cho signal intensities. The relative proton metabolite ratios of Cr/Cho, GABA/NAA and GABA/Cho were
significantly
increased, but NAA/Cr was significantly decreased in schizophrenics(P<0.01). It appears that localized, water suppressed in vivo 1H MRS is a useful research and diagnostic tool in the study of schizophrenia and perhaps also in the other
psychiatric
and/or brain disorders.
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